บทคัดย่องานวิจัย

หมวดหมู่ : ฐานข้อมูลงานวิจัย

Need to determine the relative developmental risks of Fusarium mycotoxin dexoynivalenol (DON) and benomyl (BEN) in wheat.

HICKS, L.R., BROWN, D.R., STORCH, R.H. and BUSHWAY, R.J.

Human and Ecological Risk Assessment 6: 341-354.

2000

บทคัดย่อ

Need to determine the relative developmental risks of Fusarium mycotoxin dexoynivalenol (DON) and benomyl (BEN) in wheat.

Fungal infection of wheat which results in DON contamination can be suppressed with benomyl (BEN). Under certain exposure laboratory conditions both DON and BEN are developmental toxins. Since use of BEN may result in concurrent dietary exposure to both compounds, evaluation of the relative developmental risks is needed. A modified margin of exposure (modMOE) was developed using “A” kg (food)/kg (body weight) as the constant for wheat consumption. The modMOE for DON is 28/a and that for BEN is 1667/a. Comparative relative risks can be expressed as the ratio of BEN risks to DON risks (60). Treatment with BEN at the most efficacious time decreased DON levels to 34% of controls, and decreased the comparative risk ratio from 6 To 18. The potential for fungicides to decrease mycotoxin health risks is important in the safety assessment for foodstuffs. This approach improves on current practices for food safety assessment by including the expected reductions in risks from naturally occurring mycotoxins in the regulatory analysis.