An investigation on the antimutagenic properties of South African herbal teas.
MARNEWICK, J.L., GELDERBLOM, W.C.A. and JOUBERT, E.
Mutaation Research-Genetic Toxicology and Environmental Mutagenesis 471: 157-166.
2000
บทคัดย่อ
The antimutagenic properties of South African herbal teas were investigated using the Salmonella typhimurium mutagenicity assy. Aqueous extracts of fermented and unfermented rooibos tea (Aspalathus linearis) and honeybush tea (Cyclopia intermedia) both possess antimutagenic activity against strains AFB1 induced mutagenesis using tester strains TA98 and TA100 in the presence of metabolic activation. The data suggest that two mechanisms are involed in the antimutagenicity of the tea extracts towards carcinogens that require metabolic activation: the tea components may interfere with cytochrome P350-mediated metabolism of these mutagens, and the direst interaction between the tea constituents, presumably the polyphenolic compounds, with the promutagens and/or the active mutagenic metabolites.