บทคัดย่องานวิจัย

หมวดหมู่ : ฐานข้อมูลงานวิจัย

Secalonic acid D alters the nature of and inhibits the binding of the transcription factors to the phorbol 12 – O –tetradecanoate – 13 acetate – response element in the developing murine secondary palate.

BALASUBRAMANIAN, G., HANUMEGOWDA,U. and REDDY,C.S.

Toxicology and Applied Pharmacology 169: 142 – 150.

2000

บทคัดย่อ

Secalonic acid D alters the nature of and inhibits the binding of the transcription factors to the phorbol 12 – O –tetradecanoate – 13 acetate – response element in the developing murine secondary palate.

Secalonic acid D which is produced by Penicillium axalicum in corn, induces cleft palate in the offspring of exposed female mice. Results of recent studies suggest that protein kainase C (PKC) inhibition by secalonic acid D may be relevant to its cleft palate induction. Dowinstream effects of PKC are determined by the nature of transcription factors (TF) thant form the activator protein – 1 (AP – 1) and the binding of AP – 1 (and other TF_ to the phorbol 12 – O – tetradecanoate – 13 acetate – response element (TRE) to form AP – 1 – TRE complex. Results suggest that a dynamic shift in the binding of TF to TRE from PKA – to PKC – responsive TF occurs during patlate development and that teratogens such as secalonic acid D can alter bothe the nature and extent of TF binding to TRE.

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