บทคัดย่องานวิจัย

หมวดหมู่ : ฐานข้อมูลงานวิจัย

Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis.

JARVIS, B.B., SORENSON, W.G., HINTIKKA, E.L., NIKULIN, M., ZHOU, Y.H., JIANG.J., WANG, S.G., HINKLEY, S., ETZEL, R.A. and DEARBORN, D.

Applied and Environmental Microbiology 64: 3620 – 3625.

1998

บทคัดย่อ

Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis.

A cluster of cases of pulmonary hemosiderosis among infants was reported in Cleveland, Ohio, during 1993 and 1994. These unusual cases appeared only in infants ranging in age from 1 to 8 months and were characterised by pulmonary haemorrhage. A case control study identified major home water damage (from plumbing leaks, roof leaks or flooding) as a risk factor for development of pulmonary haemorrhage in these infants. A number of Stachybotrys chartarum isolates collected from the homes were grown on rice, and extracts were analysed both for cytotoxicity and for specific toxins. Two isolates of Memnoniella echinata, a fungus closely related to S.chartarum, were also included in these studies. S.chartarum, were also included in these studies. S.chartarum isolates produced a number of highly toxic compounds, and the profiles of toxic compounds from M.echinata were similar. The most notable difference was the fact that the principal metabolites produced by M.echinata were griseofulvins.