Biosynthetic studies of fumonisin B1 and AAL toxins.
Caldas, E.D., Sadilkova, K., Ward, B.L., Jones. A.D., Winter, C.K. and Gilchrist, D.G.
Journal of Agricultural and Food Chemistry 46: 4734 – 4743.
1998
บทคัดย่อ
The biosynthesis of FB1 and the AAL toxins was studied by growing Fusarium moniliforme and Alternaria alternata f. sp. Lycopersici in liquid culture with radioactive and stable isotopically labelled amono acid, water, and molecular oxygen precursors. Results indicated that glycine was incorporated directly into the AAL toxins and that methionine was incorporated into the AAL toxin methyl groups. Oxygens in tricarballylic acid moieties for FB1 and the AAL toxins originated from molecular oxygen. Isotopic enrichment patterns for the various AAL toxins showed marked differences among toxins, suggesting a complex, rather than sequential, biosynthetic pattern.