Structures and biosynthesis of aflastatins – novel inhibitors of aflatoxin production by Aspergillus parasiticus.
ONO, M., SAKUDA, S., IKEDA, H., FURIHATA, K., NAKAYAMA, J., SUZUDI, A. and ISOGAI, A.
Journal of Anitbiotics 51 : 1019 – 1028.
1998
บทคัดย่อ
Two novel inhibitors of aflatoxin production by Aspergillus parasiticus were isolated from the mycelial extracts of Streptomyces sp. MRI 142 and termed aflastatin A and B. The structures of aflastatin A and B were elucidated by NMR and chemical degradation experiments. These compounds have a novel skeleton of a tetramic acid derivative with a highly oxygenated long alky1 chain.