Inhibition of aflatoxin B1 biosynthesis in Aspergillus flavus by anthocyanidins and related flavonoids.
NORTON, R.A.
Journal of Agricultural and Food Chemistry 47 : 1230-1235.
1999
บทคัดย่อ
Anthocyanidins and precursors or related flavonoids were tested at concentrations from 0.3 to 9.7 mM (similar to 0.1-3.0 g/L) for activity against growth and AFB1 biosynthesis by Aspergillus flavus. AFB1 production was inhibited by all anthocyanidins tested, and 3-hydroxy compounds were more active than 3-deoxy forms. Monoglycosides of cyanidin were 40% less inhibitory than the aglycon, whereas a monoglucoside and a diglucoside of pelargonidin were 80 and 5%, respectively, as active as the aglycon. Of eight flavonoids tested, only kaempferol was moderately active, whereas luteolin and catechin were weakly inhibitory. Results with an aflatoxin pathway mutant indicated that anthocyanidin inhibition occurred before norsolorinic acid synthesis.