ศูนย์นวัตกรรมเทคโนโลยีหลังการเก็บเกี่ยว

Incorporation of molecular oxygen in aflatoxin B1 biosynthesis.

WATANABE, C.M.H. and TOWNSEND, C.A.

Journal of Organic Chemistry 61 : 1990-1993.

1996

บทคัดย่อ

The incorporation of [¹⁸O]oxygen in the biosynthesis of AFB₁ is reported.  This allows a minimal mechanism to be proposed where a monooxygenase activation of the xanthone is followed by a dioxygenase mediated aryl cleavage to initiate the final rearrangement and decarboxylation to AFB₁.  Similarly, two other sites of heavy oxygen incorporation are consistent with proposed Baeyer-Villiger-like reactions taking place earlier in the pathway.